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1DegreeBio's Epigenetic Crossword
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Epigenome: chemical changes to the DNA and histones of an organism - think big!
Methylation: covalent DNA modification that represses transcription
HAT: an enzyme that acetylates lysine on histone proteins, or an item of clothing (acronym)
HDAC: an enzyme that removes acetyl groups from histone proteins (acronym)
Denovo: “from the beginning” in latin (two words)
Maintenance: DNMT1 is the __________ DNA methyltransferase
octamer: H2a, H2b, H3, H4 (twice)
ChIP: a technique used to study protein - chromatin interaction (acronym)
MeDIP: a technique used to separate methylated from non-methylated DNA (acronym)
Hydroxymethylcytosine: the 6th base pair (without the 5-)
Histones: basic proteins commonly associated with DNA, can be “core” or “linker”
Beadsonastring: what you see under an electron microscope when DNA wraps around histone proteins forming nucleosomes, or a bracelet (4 words)
Noncoding: long ________ RNA
XIST: RNA that plays an important role in X-chromosome inactivation (acronym)
Polycomb: this complex mediates the addition of the methyl groups in H3K27me3
Trithorax: this group of proteins activates the Hox genes during development
Progeria: a rare genetic condition that produces rapid aging in children, associated with a mutated version of nuclear lamin A
Rettsyndrome: a neurodevelopmental disorder caused by mutations in the MECP2 gene located on the X chromosome (2 words)
Imprinting: the process of expressing genes in a parent of origin specific manner, ie. H19 and IGF2 loci
Bioinformatics: application of computer science and IT to biology, especially with huge data sets
Promoter: a region of DNA that facilitates the transcription of a particular gene, it may be TATA-less
CpGisland: a genomic region that contain a high frequency of cytosines and guanines (2 words)
Intergenic: a stretch of DNA located between genes that contain few or no genes
Centromere: where sister chromatids meet
Telomere: the end of a chromosome
Transcription factor: a protein that binds to specific DNA sequences (2 words)
Heterochromatin: tightly coiled, transcriptionally inactive DNA
Reprogramming: erasure and remodeling of epigenetic marks that occurs during mammalian development of germ cells and as fibroblasts are turned into iPS cells
Monozygotic: identical (twins), originating from a single egg
somatic: ____ cell nuclear transfer involves the transfer of a nucleus from one cell to the cytoplasm of an enucleated egg
sodiumbisulfite: a chemical that deaminates cytosine into uracil, but does not affect methylated cytosines (2 words)
MSPI: a restriction enzyme, the isoschizomer of HpaII
1DegreeBio's Epigenetic Crossword
Across:4. | a technique used to separate methylated from non-methylated DNA (acronym) | 5. | tightly coiled, transcriptionally inactive DNA | 8. | “from the beginning” in latin (two words) | 9. | a protein that binds to specific DNA sequences (2 words) | 11. | this group of proteins activates the Hox genes during development | 14. | a chemical that deaminates cytosine into uracil, but does not affect methylated cytosines (2 words) |
| 15. | application of computer science and IT to biology, especially with huge data sets | 17. | a region of DNA that facilitates the transcription of a particular gene, it may be TATA-less | 20. | DNMT1 is the __________ DNA methyltransferase | 27. | a neurodevelopmental disorder caused by mutations in the MECP2 gene located on the X chromosome (2 words) | 28. | the process of expressing genes in a parent of origin specific manner, ie. H19 and IGF2 loci | 30. | a stretch of DNA located between genes that contain few or no genes |
| | Down:1. | an enzyme that acetylates lysine on histone proteins, or an item of clothing (acronym) | 2. | an enzyme that removes acetyl groups from histone proteins (acronym) | 3. | what you see under an electron microscope when DNA wraps around histone proteins forming nucleosomes, or a bracelet (4 words) | 6. | the 6th base pair (without the 5-) | 7. | ____ cell nuclear transfer involves the transfer of a nucleus from one cell to the cytoplasm of an enucleated egg | 10. | H2a, H2b, H3, H4 (twice) | 12. | a technique used to study protein - chromatin interaction (acronym) | 13. | erasure and remodeling of epigenetic marks that occurs during mammalian development of germ cells and as fibroblasts are turned into iPS cells | 16. | identical (twins), originating from a single egg | 18. | chemical changes to the DNA and histones of an organism - think big! |
| 19. | long ________ RNA | 20. | covalent DNA modification that represses transcription | 21. | where sister chromatids meet | 22. | a genomic region that contain a high frequency of cytosines and guanines (2 words) | 23. | a rare genetic condition that produces rapid aging in children, associated with a mutated version of nuclear lamin A | 24. | the end of a chromosome | 25. | this complex mediates the addition of the methyl groups in H3K27me3 | 26. | basic proteins commonly associated with DNA, can be “core” or “linker” | 29. | RNA that plays an important role in X-chromosome inactivation (acronym) |
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© 2012
PuzzleFast.com, Noncommercial Use Only
1DegreeBio's Epigenetic Crossword
Across:4. | a technique used to separate methylated from non-methylated DNA (acronym) | 5. | tightly coiled, transcriptionally inactive DNA | 8. | “from the beginning” in latin (two words) | 9. | a protein that binds to specific DNA sequences (2 words) | 11. | this group of proteins activates the Hox genes during development | 14. | a chemical that deaminates cytosine into uracil, but does not affect methylated cytosines (2 words) |
| 15. | application of computer science and IT to biology, especially with huge data sets | 17. | a region of DNA that facilitates the transcription of a particular gene, it may be TATA-less | 20. | DNMT1 is the __________ DNA methyltransferase | 27. | a neurodevelopmental disorder caused by mutations in the MECP2 gene located on the X chromosome (2 words) | 28. | the process of expressing genes in a parent of origin specific manner, ie. H19 and IGF2 loci | 30. | a stretch of DNA located between genes that contain few or no genes |
| | Down:1. | an enzyme that acetylates lysine on histone proteins, or an item of clothing (acronym) | 2. | an enzyme that removes acetyl groups from histone proteins (acronym) | 3. | what you see under an electron microscope when DNA wraps around histone proteins forming nucleosomes, or a bracelet (4 words) | 6. | the 6th base pair (without the 5-) | 7. | ____ cell nuclear transfer involves the transfer of a nucleus from one cell to the cytoplasm of an enucleated egg | 10. | H2a, H2b, H3, H4 (twice) | 12. | a technique used to study protein - chromatin interaction (acronym) | 13. | erasure and remodeling of epigenetic marks that occurs during mammalian development of germ cells and as fibroblasts are turned into iPS cells | 16. | identical (twins), originating from a single egg | 18. | chemical changes to the DNA and histones of an organism - think big! |
| 19. | long ________ RNA | 20. | covalent DNA modification that represses transcription | 21. | where sister chromatids meet | 22. | a genomic region that contain a high frequency of cytosines and guanines (2 words) | 23. | a rare genetic condition that produces rapid aging in children, associated with a mutated version of nuclear lamin A | 24. | the end of a chromosome | 25. | this complex mediates the addition of the methyl groups in H3K27me3 | 26. | basic proteins commonly associated with DNA, can be “core” or “linker” | 29. | RNA that plays an important role in X-chromosome inactivation (acronym) |
| |
© 2012
PuzzleFast.com, Noncommercial Use Only